Haptoglobin (HP) Test Test
This test measures the amount of haptoglobin in your blood. Haptoglobin is a protein made by your liver that binds to hemoglobin released from red blood cells, helping your body remove it. Low levels can indicate red blood cell disorders like hemolytic anemia.
What this test measures
This test measures the amount of haptoglobin in your blood. Haptoglobin is a protein made by your liver to get rid of the hemoglobin outside your red blood cells.
What your results mean
Reference ranges vary by laboratory and by your age and sex. MedlinePlus does not publish a single normal range for this test — always read your result against the range printed on your own lab report and discuss it with your provider.
Higher-than-normal results
A haptoglobin level that is higher than normal may be a sign of: Ulcerative colitis, Acute rheumatic disease, such as arthritis or other conditions that affect the joints, bones, and muscles, A severe infection, Diabetes.
Lower-than-normal results
A haptoglobin level that is lower than normal may be a sign of: Hemolytic anemia, Liver disease, Reaction to a transfusion.
Frequently asked questions
What is haptoglobin?
Haptoglobin is a protein made by your liver that binds to hemoglobin released from red blood cells, helping your body remove it.
Why is this test done?
This test is most often used to diagnose hemolytic anemia, a disorder where red blood cells are destroyed faster than they can be replaced.
What does a low haptoglobin level mean?
A low level may be a sign of hemolytic anemia, liver disease, or a reaction to a transfusion. It is normal for infants less than six months old.
What does a high haptoglobin level mean?
A high level may be a sign of ulcerative colitis, acute rheumatic disease, a severe infection, or diabetes.
Will I need other tests?
Your provider may order other blood tests such as reticulocyte count, hemoglobin test, hematocrit test, lactate dehydrogenase test, blood smear, or complete blood count to help make a diagnosis.
Related lab tests
Sources
- MedlinePlus: Haptoglobin (HP) Test — NIH MedlinePlus
Last updated . Information is aggregated from official public sources and is not a substitute for professional medical care.