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Acamprosate Calcium

Brand names: Acamprosate Calcium

Acamprosate calcium is a prescription medicine used to help people with alcohol dependence stay alcohol-free after they have stopped drinking.

What it is used for

Acamprosate calcium delayed-release tablets are used to maintain abstinence from alcohol in patients with alcohol dependence who have already stopped drinking at the start of treatment. It should be part of a comprehensive management program that includes psychosocial support.

How it is taken

The recommended dose is two 333 mg tablets (total 666 mg) taken three times daily. For patients with moderate kidney problems (creatinine clearance 30 to 50 mL/min), the dose is one 333 mg tablet taken three times daily. Do not use in patients with severe kidney problems (creatinine clearance ≤30 mL/min). Treatment should start as soon as possible after alcohol withdrawal when the patient is abstinent. It may be taken with or without food, but taking with meals is suggested for those who eat three meals daily.

Warnings

  • Acamprosate calcium is contraindicated in patients with severe renal impairment (creatinine clearance ≤30 mL/min).
  • Serious adverse reactions include suicidality, depression, and acute kidney failure.
  • In clinical trials, 8% of patients stopped treatment due to side effects, most commonly diarrhea.

Common side effects

  • Accidental injury
  • Asthenia (weakness)
  • Pain
  • Anorexia
  • Diarrhea
  • Flatulence
  • Nausea
  • Anxiety
  • Depression
  • Dizziness
  • Dry mouth
  • Insomnia
  • Paresthesia (tingling or numbness)
  • Pruritus (itching)
  • Sweating

Interactions

Acamprosate does not affect the pharmacokinetics of alcohol. The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram. Clinically important interactions between naltrexone and acamprosate were not observed.

This summary is written in plain language from the official FDA label. Always follow the directions from your own prescriber and pharmacist, and read the full label linked below.

Frequently asked questions

What is acamprosate calcium used for?

Acamprosate calcium is used to help people with alcohol dependence stay alcohol-free after they have stopped drinking. It should be part of a comprehensive program that includes psychosocial support.

How should I take acamprosate calcium?

The usual dose is two 333 mg tablets three times daily. If you have moderate kidney problems, your doctor may reduce the dose to one 333 mg tablet three times daily. Do not take it if you have severe kidney problems.

What are common side effects?

Common side effects include diarrhea, nausea, anxiety, insomnia, weakness, and itching. Diarrhea was the most common reason for stopping treatment.

Can I drink alcohol while taking acamprosate calcium?

Acamprosate is used to maintain abstinence, so you should not drink alcohol. The label states that acamprosate does not affect how alcohol works in the body, but the goal is to stay alcohol-free.

Does acamprosate interact with other medicines?

Acamprosate does not interact with alcohol, diazepam, disulfiram, or naltrexone in a clinically important way. Always tell your doctor about all medicines you take.

Other medications

Sources

Last updated . Information is aggregated from official public sources and is not a substitute for professional medical care.